Number 1. (in 1 part) September 12, 2014

Abstract:
The article features the research results of psychological status and the nervous system. The study was conducted on the basis of multivariate analysis of morbidity rates of the nervous system with the aim of developing of administrative actions towards the population of Ust-Kamenogorsk. The correlation analysis has shown that the of coefficients of correlation coincide with the analysis data of morbidity rates of the nervous system showing that that morbidity rates are mostly influenced by high concentration of harmful pollutants. Besides, the correlation analysis has allowed identifying the levels of pollution in the atmosphere of the city above which the interrelation between fluctuations of morbidity rates is shown and below which correlation has been not observed. From the provided data we can see that the main sources of harmful substances entering our bodies are polluted atmospheric air and soils. The study revealed that with the growth of anthropogenesis loading by toxic metals, the morbidity rates of encephalopathies of unspecified genesis and the cerebrovascular diseases increase. Changes in psycho-emotional sphere have been revealed. The novelty of research is the development of administrative procedures aimed at reduction of the disease prevalence for people living in Ust-Kamenogorsk.

URL: http://ejournal5.com/journals_n/1410505745.pdf
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Abstract:
Under the impact of production factors on miners, the decrease in amplitude of biopotentials of front/back group of muscles-agonist and hip muscles-antagonists is a sign of decrease of afferentation and the development of braking process on the level of segmentary apparatus and the most expressed in seniority groups of 5–10 and 11–15 years. This tendency has been existing since a new morbidity act is made. Patients with early manifestations of chronic lumbosacral radiculopathy showed an increase in muscle biopotentials synergists and antagonists to decrease, reflecting the increase of intracentral links in segmental apparatus.

URL: http://ejournal5.com/journals_n/1410505855.pdf
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Abstract:
In West of Algeria, incidence of prostate cancer (PCa) is growing and epidemiological data on benign prostatic hyperplasia (BPH) are contradictory. The prostate specific antigen (PSA) joins other tests, as digital rectal examination (DRE) and ultrasound, for better management of patient. This study aimed to assess the association of previously tests with PSA-assay in diagnosis of PCa and BPH, in West Algeria. A retrospective study was performed on two groups of 234 BPH and 56 PCa diagnosed between 2010–2012 at the urology department of the hospital in Saida. Patients underwent various diagnostic tests; DRE, ultrasound, PSA and pathological examination. BPH is more common than PCa and the most dominant age group was from 70 to 79 years. DRE was positive in 67 % of BPH and 63.3 % PCa. Ultrasound examination revealed that the prostatic structure was heterogeneous in 25.5 % of BPH and 92 % PCa. Total PSA (TPSA) was higher than the cut-off value of 4 ng / ml in 37% of BPH and 75 % PCa. Histological forms of Prostatic adenomyofibroma and prostatic adenocarcinoma were the most represented. This study shows that the combination of different tests is more efficient than using a test alone for a definitive diagnosis of PCa or BPH.

URL: http://ejournal5.com/journals_n/1410506029.pdf
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Abstract:
It has been performed complex examination of 60 school-aged children with bronchial asthma (30 – with symptoms of exercise-induced bronchial asthma (BAFN), 30 – with no evidence of bronchospasm with exercise), analyzed clinical, inflammatometral and instrumental performance indicators of the basic treatment. It has been demonstrated that BAFN control, which can only be achieved in 25.9 % of cases, poor clinical response to anti-inflammatory therapy, a slight tendency to normalization of nitric oxide in the airways, but statistically significant decrease in symptoms bronchi hyperresponsiveness to histamine, but not their lability.

URL: http://ejournal5.com/journals_n/1410506188.pdf
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Abstract:
In the article «Genetic factors of fibrinolysis violation and the role of inhibitor plasminogen activator genes polymorphism in the development of secondary thrombus bleeding complications in patients with brain injury», briefly summarized the impact of molecular-genetic mechanisms peculiarities on the system of hemostasis, the results of investigations were provide in case of thrombohemorrhagic complications appearance while PAI-1 plasma levels and computed tomographic manifestations changes in 200 patients with TBI, -675 gene polymorphism and PAI-1.

URL: http://ejournal5.com/journals_n/1410506272.pdf
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Abstract:
The frequency of allelic genotypes by BclI polymorphism glucocorticoids receptor gene (GR) had been studied in dependence of the control level of bronchial asthma (BA) and body mass index (BMI), and also- connection between those indicators. 188 patient with BA and 95 almost healthy humans were investigated. Determination of single nucleotide BclI polymorphism GR gene performed by the method of polymerase chain reaction with following analyze of the length of restriction fragments. Our studies demonstrated connection between BA control, BclI polymorphism GR gene and BMI. Proved, that distribution C/C, C/G and G/G genotypes by BclI polymorphism in patients with BA showed reliable difference between patients with different BMI and connection G/G genotype with obesity. The reliable difference in distributing of genotype in dependence of BA control level has been proved: with controlled BA reliably often met C/C genotype, without control – G/G genotype. Therefore, proved, that frequency G/G genotype by BclI polymorphism GR gene in patients with BA with obesity and absence of control for the flowing of disease is reliably higher, that confirmed the role of this genotype, likewise, in obesity occurrence, so in absence of the control of disease.

URL: http://ejournal5.com/journals_n/1410506375.pdf
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Abstract:
It has been performed complex examination of 150 school-aged children with bronchial asthma, which included a study of exhaled breath condensate and a determination of deletions in the genes of glutathione-S-transferase (GSTM1 and GSTT1). A greater activity of bronchial inflammation manifested by increased activity of oxidative stress with the accumulation of products of oxidative modification of proteins in exhaled breath condensate has been noticed during asthma exacerbation in children with deletion polymorphism of genes GSTT1 and GSTM1 compared with patients without those genetic changes.

URL: http://ejournal5.com/journals_n/1410506798.pdf
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Abstract:
This article examines the clustering of the parameters of rhythmographic analysis of the events of the corporate network traffic of the Cisco MARS system. The author dwells upon classifying clustering methods and illustrates a conceptual clustering algorithm. The author infers that, firstly, the results of processing experimental data derived from network traffic logs substantiate the applicability of the methodology of rhythmographic analysis, which is accepted in cardiology, in the analysis of the rhythm of appearance of events in the Cisco MARS system; secondly, the results of clustering the fragments of the rhythm of events substantiate the effectiveness of the approach proposed; thirdly, the practical application of automatic detection of anomalies in network traffic events requires further research.

URL: http://ejournal5.com/journals_n/1410506913.pdf
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Abstract:
The phylogenetic theory of general pathology postulates that notions of the biological role of arterial pressure (AP) in physiology and pathology have been subjected to inversion. The nephron’s activation of the synthesis of the components renin → angiotensin-II (A-II) and the augmentation of aldosterone secretion are directed not at an increase in AP but at preserving the volume of the piece of the third world ocean, privatized by each species, - the pool of the intercellular milieu in which, just like millions of years before, there continue to live all cells. Phylogenetically earlier organs cannot regulate the action of a later one in AP phylogenesis – a physical factor in metabolism regulation. It is not the kidneys that increase AP but the vasomotor center, which, increasing AP in the proximal segment and further hydrodynamic pressure in the distal segment of the arterial bed, seeks to reanimate the function of nephrons, the biological function of endoecology and the biological reaction of excretion. In addition to playing a major role in the biological function of locomotion, AP is a physical factor in compensating for impairments in the biological functions of homeostasis, trophology, endoecology, and adaptation. There have formed sequentially three levels of metabolic regulation in phylogenesis. At an autocrine level, there occurs a specific regulation of biochemical reactions. Within paracrinally regulated communities of cells, in the distal segment of the arterial bed, metabolism is regulated by millions of local peristaltic pumps through compensating for the biological reaction of endothelium-dependent vasodilation, microcirculation, and the action of humoral mediators and hormonal principles. In vivo from the level of the vasomotor center metabolism is non-specifically, systemically regulated by the physical factor – AP – through sympathetic activation of the heart; in the proximal segment of the arterial bed and the distal one, AP, overcoming the resistance, virtually “collapses” arterioles with impaired microcirculation. A-II acts as a vasoconstrictor only in the distal segment of the arterial bed. In the pathogenesis of essential, metabolic AH, the paracrine communities of the nephron and the kidney are involved in the realization of pathological compensation secondarily and are often “wrongfully accused”, just like the other “target organs” – the brain, the lungs, and the heart.

URL: http://ejournal5.com/journals_n/1410506994.pdf
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Abstract:
Healing of skin defect of any etiology goes through several stages, which are completed or complete restoration of the lost cover, or the formation of scar tissue that covers the injury. Regeneration of the skin is depending on the type of injury, collateral damage, existing diseases such as diabetes, obesity, immune deficiency, including AIDS. At present, in the arsenal of physicians, there are a range of materials – from human skin to materials using tissue engineering technology. However, there is no universal bandage that meets the physician and patient efficacy and pharmaco-economic indicators. Therefore, the development of new materials for local treatment of skin lesions is relevant biomedical problem. The purpose of the work. Identify the characteristics of the regeneration process of the skin after a chemical burn when using chitosan membranes. We have conducted an experiment on 180 male laboratory rats of three age groups. All animals were simulated chemical burn in the interscapular region. The control animals received standard treatment of a series of chemical burns with sterile gauze bandages, which are changed daily. Experimental series of animals for the treatment of skin lesions using chitosan hydrogel, which was applied to the damaged areas with the replacement of film 1 per day. As a result, the application of chitosan dressings observed accelerated cleansing the wound necrosis in animals of young and adult ages and full wound epithelialization till 21 day of observation. Cytological examination showed decreased number of inflammatory cells at the wound surface and increase in the number of macrophages and fibroblasts. These changes had expressed age-related and more pronounced effect in animals of young and adult ages.

URL: http://ejournal5.com/journals_n/1410507092.pdf
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URL: http://ejournal5.com/journals_n/1410507118.pdf
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