3 September 25, 2015
1. Oksana G. Cherniukh, Maryana V. Dikal
Concentration of the Main Biochemical Blood Indices in Early Postnatal Period
European Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 118-123.
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2. Georgi Gluhchev, Ignat Ignatov, Stoil Karadzhov, Georgi Miloshev, Nikolay Ivanov, Oleg MosinEuropean Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 118-123.
Abstract:
The work deals with the analysis of the umbilical blood samples (120 samples) concerning the concentration of general protein and glucose as the main biological constants of newborns. There is no a reliable difference found between these indices while comparing groups with monocyesis and twin pregnancies. Possible correlation interrelation of certain biochemical indices in newborns during early postnatal period was examined (54 samples). In addition, changes of the examined biochemical indices were followed in the course of time in 19 newborns concerning the comparison of umbilical and venous blood.
The work deals with the analysis of the umbilical blood samples (120 samples) concerning the concentration of general protein and glucose as the main biological constants of newborns. There is no a reliable difference found between these indices while comparing groups with monocyesis and twin pregnancies. Possible correlation interrelation of certain biochemical indices in newborns during early postnatal period was examined (54 samples). In addition, changes of the examined biochemical indices were followed in the course of time in 19 newborns concerning the comparison of umbilical and venous blood.
Number of views: 2191 Download in PDF
Studying the Antimicrobial and Antiviral Effects of Electrochemically Activated Nacl Solutions of Anolyte and Catholyte on a Strain of E. Coli DH5 and Classical Swine Fever (CSF) Virus
European Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 124-138.
Number of views: 2429 Download in PDF
3. Sribas Goswami, Manjari SahaiEuropean Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 124-138.
Abstract:
This paper outlines the results on the antiviral and antimicrobial action of electrochemically activated NaCl solutions (anolyte/catholyte), produced in the anode and cathode chamber of the electrolitic cell, on classical swine fever (CSF) virus and a stain of E. coli DH5. It was found that the anolyte did not affect the growth of the cell culture PK-15; the viral growth during the infection of a cell monolayer with a cell culture virus was affected in the greatest degree by the anolyte in 1:1 dilution and less in other dilutions; whereas the viral growth at the infection of a cell suspension with the CSF virus was affected by the anolyte in dilution 1:1 in the greatest degree, and less by other dilutions; viral growth at the infection with a virus in suspension of the cell monolayer was affected by the anolyte in all dilutions. Unexpectedly, the stronger biocidal effect of the catholyte was observed when a strain of E. coli DH5 was treated by the anolyte and catholyte, respectively. In order to provide additional data about the antiviral activity of the electrochemically activated water and the distribution of H2O molecules according to the energies of hydrogen bonds, the non-equilibrium energy spectrum (NES) and differential non-equilibrium energy spectrum (DNES) of the anolyte and catholyte were measured.
This paper outlines the results on the antiviral and antimicrobial action of electrochemically activated NaCl solutions (anolyte/catholyte), produced in the anode and cathode chamber of the electrolitic cell, on classical swine fever (CSF) virus and a stain of E. coli DH5. It was found that the anolyte did not affect the growth of the cell culture PK-15; the viral growth during the infection of a cell monolayer with a cell culture virus was affected in the greatest degree by the anolyte in 1:1 dilution and less in other dilutions; whereas the viral growth at the infection of a cell suspension with the CSF virus was affected by the anolyte in dilution 1:1 in the greatest degree, and less by other dilutions; viral growth at the infection with a virus in suspension of the cell monolayer was affected by the anolyte in all dilutions. Unexpectedly, the stronger biocidal effect of the catholyte was observed when a strain of E. coli DH5 was treated by the anolyte and catholyte, respectively. In order to provide additional data about the antiviral activity of the electrochemically activated water and the distribution of H2O molecules according to the energies of hydrogen bonds, the non-equilibrium energy spectrum (NES) and differential non-equilibrium energy spectrum (DNES) of the anolyte and catholyte were measured.
Number of views: 2429 Download in PDF
A Study of Psychosocial Risk Status and Knowledge of Reproductive Health in Adolescents in Raipur City
European Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 139-149.
Number of views: 2169 Download in PDF
4. Chaha Kato, Ajike S OlusegunEuropean Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 139-149.
Abstract:
Adolescence is the period of physical and psychological development from the onset of puberty to maturity. The World Health Organization defines an adolescent as a person between ages 10 and 19 years. A dramatic shift in thinking from concrete to abstract gives adolescents a whole new set of mental tools, to analyze situations logically in terms of cause and effect, appreciate hypothetical situations, evaluate alternatives, introspection, decision making and cognitive abilities. Adolescents experience intense physical, psychological changes as they make transition from childhood to adulthood. This period of transition is the most vulnerable time. Adolescents are at risk of developing behavioral problems like school failure and drop outs, substance abuse, delinquency and violence, sexually transmitted diseases, unwanted pregnancies, domestic violence, stress and depression and risk-taking behaviour. It is the responsibility of the society to utilize this period constructively through education, counseling, mass media, awareness programmes and address the reproductive health needs of adolescents. The present study analyzes the psychosocial risk status and knowledge of reproductive health in adolescents in Raipur city. The study recommends implementation of provisions by government to provide continuous education and economic security for adolescents. Programmes like age-appropriate reproductive health curriculum should be introduced in schools and colleges with counseling facilities at school and primary health care levels.
Adolescence is the period of physical and psychological development from the onset of puberty to maturity. The World Health Organization defines an adolescent as a person between ages 10 and 19 years. A dramatic shift in thinking from concrete to abstract gives adolescents a whole new set of mental tools, to analyze situations logically in terms of cause and effect, appreciate hypothetical situations, evaluate alternatives, introspection, decision making and cognitive abilities. Adolescents experience intense physical, psychological changes as they make transition from childhood to adulthood. This period of transition is the most vulnerable time. Adolescents are at risk of developing behavioral problems like school failure and drop outs, substance abuse, delinquency and violence, sexually transmitted diseases, unwanted pregnancies, domestic violence, stress and depression and risk-taking behaviour. It is the responsibility of the society to utilize this period constructively through education, counseling, mass media, awareness programmes and address the reproductive health needs of adolescents. The present study analyzes the psychosocial risk status and knowledge of reproductive health in adolescents in Raipur city. The study recommends implementation of provisions by government to provide continuous education and economic security for adolescents. Programmes like age-appropriate reproductive health curriculum should be introduced in schools and colleges with counseling facilities at school and primary health care levels.
Number of views: 2169 Download in PDF
Upper Lid Coloboma – a Case Report
European Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 150-154.
Number of views: 2277 Download in PDF
5. Nozim N. Khoshimov, Guli M. Raimova, Kabil E. Nasirov, Valentina I. VinogradovaEuropean Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 150-154.
Abstract:
The upperlid colobomas are rare and usually associated with cryptophthalmos. The colobomas can either affect one or both eyes. They can be associated with life threatening syndromes which must always be looked out for. Our case however defied any of these associations. Upper lid colobomas can lead to severe eyeball morbidities including blindness and must be attended to promptly either by conservative or surgical approaches depending on the size of the coloboma, the associated ocular morbidities and the age of the patient. The prognosis of the pathology is fairly good depending also on the surgeon’s expertise and time of presentation of the patient to the surgeon.
The upperlid colobomas are rare and usually associated with cryptophthalmos. The colobomas can either affect one or both eyes. They can be associated with life threatening syndromes which must always be looked out for. Our case however defied any of these associations. Upper lid colobomas can lead to severe eyeball morbidities including blindness and must be attended to promptly either by conservative or surgical approaches depending on the size of the coloboma, the associated ocular morbidities and the age of the patient. The prognosis of the pathology is fairly good depending also on the surgeon’s expertise and time of presentation of the patient to the surgeon.
Number of views: 2277 Download in PDF
Comparison of Hemostatic and Neuro Protector Properties of Alkaloids N-Metiltsitizin and a Desoxypeganin in the Conditions of in Vitro
European Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 155-169.
Number of views: 2209 Download in PDF
6. Shunkor Khushmatov, Kamila Eshbakova, Diloram AlimovaEuropean Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 155-169.
Abstract:
Modeling of sharp alcoholic intoxication induced animal 6 mg/kg of 50-70% ethanol by introduction. On this background studied effects of N-metilsitizin alkaloids and a desoxypeganin on ADP-induced aggregation of platelets and level of intracellular Ca2+ in the synaptosomes of a brain of rats. The obtained data render that the inhibiting effect of N-metilsitizin alkaloids and a desoxypeganin on ADP-induced aggregation of platelets is connected with oppression of a gain of cytoplasmatic concentration of Ca2+ from depot of platelets. Thus, N-metiltsitizin alkaloids and desoxypeganin block a gain of level of intracellular Ca2+ at the expense of increase in Ca2+ EPR pool, provoked by ethanol. N-metiltsitizin doesn’t compete with a glutamate for a binding site. Perhaps, action of N-metiltsitizin is caused by interaction with ionic channels of NMDA receptors. The neuronal of the receptors involved in the mechanisms which are the cornerstone of AAS (including convulsive attacks) and effectively to stop to possibility of application of N-metilsitizin in regulation of dihydropyridine-sensitive calcic channels of the main subtypes them. It is shown that the possible competition between desoxypeganin and a glutamate for a site of binding of regulation of opening of ionic channels. Desoxypeganin directly doesn't affect calcic canals of a NMDA receptor. Perhaps, desoxypeganin like a glutamate causes overexcitation of NMDA receptors.
Modeling of sharp alcoholic intoxication induced animal 6 mg/kg of 50-70% ethanol by introduction. On this background studied effects of N-metilsitizin alkaloids and a desoxypeganin on ADP-induced aggregation of platelets and level of intracellular Ca2+ in the synaptosomes of a brain of rats. The obtained data render that the inhibiting effect of N-metilsitizin alkaloids and a desoxypeganin on ADP-induced aggregation of platelets is connected with oppression of a gain of cytoplasmatic concentration of Ca2+ from depot of platelets. Thus, N-metiltsitizin alkaloids and desoxypeganin block a gain of level of intracellular Ca2+ at the expense of increase in Ca2+ EPR pool, provoked by ethanol. N-metiltsitizin doesn’t compete with a glutamate for a binding site. Perhaps, action of N-metiltsitizin is caused by interaction with ionic channels of NMDA receptors. The neuronal of the receptors involved in the mechanisms which are the cornerstone of AAS (including convulsive attacks) and effectively to stop to possibility of application of N-metilsitizin in regulation of dihydropyridine-sensitive calcic channels of the main subtypes them. It is shown that the possible competition between desoxypeganin and a glutamate for a site of binding of regulation of opening of ionic channels. Desoxypeganin directly doesn't affect calcic canals of a NMDA receptor. Perhaps, desoxypeganin like a glutamate causes overexcitation of NMDA receptors.
Number of views: 2209 Download in PDF
The Inotropic Effects of 3'4'-Dimetyl Quercetin in Isolated Rat Papillary Muscle
European Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 170-179.
Number of views: 2217 Download in PDF
7. Goh Bee See, Nurfarissa binti HussinEuropean Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 170-179.
Abstract:
The aim of the present study was to determine the inotropic effect of 3'4'-dimethyl quercetin in the rat myocardium. Isometric tension forces were recorded using a force transducer (Type F30/Model D-79232; Hugo Sachs Elektronik, March-Hugstetten, Germany). 3',4'-dimethyl quercetin (10–100 μmol.L–1) exerts a positive inotropic effect in rat papillary muscles. Thus, inhibitor potential-dependent Са2+L-channels – nifedipine and inhibitor β-adrenoreceptor – propranolol has almost completely abolished the positive inotropic effects of 3',4'-dimethyl quercetin. Moreover, it was identified that the 3',4'-dimethyl quercetin depending on dose has increased quantity of the maximum velocity of force development, and the maximum velocity of papillary muscles relaxation. In conclusion, the present study demonstrates that 3',4'-dimethyl quercetin has showed a positive inotropic effect on rat papillary muscles that can be explained with the increase of [cAMP]in and may depend on increase of [Са2+]in. Furthermore, lusitropic effect of 3',4'-dimethyl quercetin can be increased in cAMP and inhibition of phosphodiesterase enzyme activates protein kinase A, which phosphorylates regulator protein activity Са2+-ATPase – phospholamban and RyRs.
The aim of the present study was to determine the inotropic effect of 3'4'-dimethyl quercetin in the rat myocardium. Isometric tension forces were recorded using a force transducer (Type F30/Model D-79232; Hugo Sachs Elektronik, March-Hugstetten, Germany). 3',4'-dimethyl quercetin (10–100 μmol.L–1) exerts a positive inotropic effect in rat papillary muscles. Thus, inhibitor potential-dependent Са2+L-channels – nifedipine and inhibitor β-adrenoreceptor – propranolol has almost completely abolished the positive inotropic effects of 3',4'-dimethyl quercetin. Moreover, it was identified that the 3',4'-dimethyl quercetin depending on dose has increased quantity of the maximum velocity of force development, and the maximum velocity of papillary muscles relaxation. In conclusion, the present study demonstrates that 3',4'-dimethyl quercetin has showed a positive inotropic effect on rat papillary muscles that can be explained with the increase of [cAMP]in and may depend on increase of [Са2+]in. Furthermore, lusitropic effect of 3',4'-dimethyl quercetin can be increased in cAMP and inhibition of phosphodiesterase enzyme activates protein kinase A, which phosphorylates regulator protein activity Са2+-ATPase – phospholamban and RyRs.
Number of views: 2217 Download in PDF
A Case Series: Outcome of Endoscopic Electrocautery in the Management of Branchial Fistula
European Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 180-186.
Number of views: 2353 Download in PDF
8. European Journal of Medicine, 2015, Vol.(9), Is. 3, pp. 180-186.
Abstract:
Objective: This is a series of five cases of branchial anomalies which were diagnosed and treated in a span of six years in the Department of Otorhinolaryngology, Head & Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre (UKMMC). The main objective of this article is to highlight the use of endoscopic electrocautery in the management of branchial fistula. Case report: five cases were reported of the age group between 11 months old to 16 years who presented with an intermittent mucoid discharge from an external opening in the neck since birth and three cases were on the left side and the other two cases were bilateral fistula. Direct laryngoscopy under general anaesthesia was done as part of diagnostic and therapeutic management for the patients. Conclusion: Endoscopic electrocautery is a safe method and appears to be an effective alternative to open excision for branchial fistula.
Objective: This is a series of five cases of branchial anomalies which were diagnosed and treated in a span of six years in the Department of Otorhinolaryngology, Head & Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre (UKMMC). The main objective of this article is to highlight the use of endoscopic electrocautery in the management of branchial fistula. Case report: five cases were reported of the age group between 11 months old to 16 years who presented with an intermittent mucoid discharge from an external opening in the neck since birth and three cases were on the left side and the other two cases were bilateral fistula. Direct laryngoscopy under general anaesthesia was done as part of diagnostic and therapeutic management for the patients. Conclusion: Endoscopic electrocautery is a safe method and appears to be an effective alternative to open excision for branchial fistula.
Number of views: 2353 Download in PDF