1 March 01, 2019
Articles and Statements
1. Igor Akszjonovics, Ignat Ignatov
Methods for Research of Effects of Device ABIEM. Applications
European Journal of Medicine, 2019, 7(1): 3-20.
Number of views: 1091 Download in PDF
2. Aleksandr Е. ErmolenkoEuropean Journal of Medicine, 2019, 7(1): 3-20.
Abstract:
This paper presents the results of evaluation of possible biophysical methods and approaches for registering of various non-ionizing radiation (NIR) wave types of the human body in the electromagnetic range after the influence of device ABIEM (Akszjonovics, 2006). Many types of NIR (electromagnetic waves, infrared radiation, thermo radiation, bioluminescence) emitted from the human body were reviewed. In particular the results on of spontaneous biophoton emission and delayed luminescence from the human body are submitted along with infrared thermography (IRT) results. It was shown that 1 cm2 of skin generally emits 85 photones for 1s. The intensity of biophoton emission ranges from 10−19 to 10−16 W/cm2 (approx. 1–1000 photons.cm-2.s-1). The specific photon emission from part of the human thumb was detected as a spectrum of various colors after influence of ABIEM with the method of Color coronal spectral analysis (Ignatov, 2007) on a device with an electrode made of polyethylene terephthalate (PET hostafan) with applied electric voltage 15 kV, electric impulse duration 10 s, and electric current frequency 15 kHz. It was established that photons corresponding to a red color emission of visible electromagnetic spectrum have energy at 1.82 еV. The orange color of visible electromagnetic spectrum has energy at 2.05, yellow – 2.14, blue-green (cyan) – 2.43, blue – 2.64, and violet – 3.03 eV. The reliable result measurement norm was at E ≥ 2.53 eV, while the spectral range of the emission was within 380–495 nm and 570–750 nm±5 nm. Also were estimated some important physical characteristics (energy of hydrogen bonds, wetting angle, surface tension) of water by the methods of non-equilibrium energy (NES) and differential non-equilibrium energy (DNES) spectrum of water (Antonov, 1990; Ignatov, 1998), that helps understand in general how electromagnetic radiation interacts with water and establish the structural characteristics of water.
This paper presents the results of evaluation of possible biophysical methods and approaches for registering of various non-ionizing radiation (NIR) wave types of the human body in the electromagnetic range after the influence of device ABIEM (Akszjonovics, 2006). Many types of NIR (electromagnetic waves, infrared radiation, thermo radiation, bioluminescence) emitted from the human body were reviewed. In particular the results on of spontaneous biophoton emission and delayed luminescence from the human body are submitted along with infrared thermography (IRT) results. It was shown that 1 cm2 of skin generally emits 85 photones for 1s. The intensity of biophoton emission ranges from 10−19 to 10−16 W/cm2 (approx. 1–1000 photons.cm-2.s-1). The specific photon emission from part of the human thumb was detected as a spectrum of various colors after influence of ABIEM with the method of Color coronal spectral analysis (Ignatov, 2007) on a device with an electrode made of polyethylene terephthalate (PET hostafan) with applied electric voltage 15 kV, electric impulse duration 10 s, and electric current frequency 15 kHz. It was established that photons corresponding to a red color emission of visible electromagnetic spectrum have energy at 1.82 еV. The orange color of visible electromagnetic spectrum has energy at 2.05, yellow – 2.14, blue-green (cyan) – 2.43, blue – 2.64, and violet – 3.03 eV. The reliable result measurement norm was at E ≥ 2.53 eV, while the spectral range of the emission was within 380–495 nm and 570–750 nm±5 nm. Also were estimated some important physical characteristics (energy of hydrogen bonds, wetting angle, surface tension) of water by the methods of non-equilibrium energy (NES) and differential non-equilibrium energy (DNES) spectrum of water (Antonov, 1990; Ignatov, 1998), that helps understand in general how electromagnetic radiation interacts with water and establish the structural characteristics of water.
Number of views: 1091 Download in PDF
The Roots and Mechanisms of Oncology
European Journal of Medicine, 2019, 7(1): 21-29.
Number of views: 1081 Download in PDF
3. Naina Mohamed Pakkir MaideenEuropean Journal of Medicine, 2019, 7(1): 21-29.
Abstract:
The theory of somatic mutations is incorrect, and the concept of “mutation” is incorrectly used. Etiological classification of tumors: 1) Tumors of malignant proliferation. Tumor cells are not specific. Tumor growth of malignant proliferation is provided by the reproduction of normal cells. The trigger mechanism of division is the interrelated actions of all the constituent parts of the tissue. The tumor mass increases due to the division of normal cells during its stimulation and dysfunction of its inhibitors and due to the predominance of cell proliferation over apoptosis. Calcium contributes to the formation of an independent structure. A tumor is a hierarchical system of its tissue and distant parts (metastases) that carry out the mutual influence. 2) Transgenic (infectious) tumors – a hybrid of a somatic cell and a microbe. They may be contagious. 3) Gestational tumors. 4) Tumors of genetic aberrations.
The theory of somatic mutations is incorrect, and the concept of “mutation” is incorrectly used. Etiological classification of tumors: 1) Tumors of malignant proliferation. Tumor cells are not specific. Tumor growth of malignant proliferation is provided by the reproduction of normal cells. The trigger mechanism of division is the interrelated actions of all the constituent parts of the tissue. The tumor mass increases due to the division of normal cells during its stimulation and dysfunction of its inhibitors and due to the predominance of cell proliferation over apoptosis. Calcium contributes to the formation of an independent structure. A tumor is a hierarchical system of its tissue and distant parts (metastases) that carry out the mutual influence. 2) Transgenic (infectious) tumors – a hybrid of a somatic cell and a microbe. They may be contagious. 3) Gestational tumors. 4) Tumors of genetic aberrations.
Number of views: 1081 Download in PDF
Drug Interactions of Acetaminophen (Paracetamol) involving CYP and UGT Enzymes
European Journal of Medicine, 2019, 7(1): 30-34.
Number of views: 1114 Download in PDF
4. Gobinath Manavalan, Naina Mohamed Pakkir Maideen, Kandukuri Varun, K. Charitha Lakshmi, P. Kavya Sri, CH Sri Durga Padmaja, P. SudharaniEuropean Journal of Medicine, 2019, 7(1): 30-34.
Abstract:
Acetaminophen (Paracetamol) is the most frequently used Over-The-Counter (OTC) antipyretic and analgesic drug, worldwide. The metabolism of Acetaminophen is mediated by phase II reactions (UDP-glucuronosyl transferases (UGT)-mediated glucuronidation and sulfation) and phase I oxidative reactions mediated by Cytochrome P450 (CYP) enzymes including CYP2E1 and CYP1A2. The drugs inducing CYP2E1 and CYP1A2 enzymes and the drugs inhibiting UDP-glucuronosyl transferases (UGTs) may increase the exposure of NAPQI resulting in elevated risk of hepatotoxicity. The risk of acetaminophen-associated hepatotoxicity might be elevated due to concomitant use of certain medications including Isoniazid, Antiepileptic drugs, Tyrosine kinase inhibitors and Alcohol. Acetaminophen may increase the international normalized ratio (INR) by potentiating the anticoagulant effect of warfarin. To prevent possible adverse drug interactions, the prescribers and pharmacists must discuss with their patients about the use of OTC Acetaminophen.
Acetaminophen (Paracetamol) is the most frequently used Over-The-Counter (OTC) antipyretic and analgesic drug, worldwide. The metabolism of Acetaminophen is mediated by phase II reactions (UDP-glucuronosyl transferases (UGT)-mediated glucuronidation and sulfation) and phase I oxidative reactions mediated by Cytochrome P450 (CYP) enzymes including CYP2E1 and CYP1A2. The drugs inducing CYP2E1 and CYP1A2 enzymes and the drugs inhibiting UDP-glucuronosyl transferases (UGTs) may increase the exposure of NAPQI resulting in elevated risk of hepatotoxicity. The risk of acetaminophen-associated hepatotoxicity might be elevated due to concomitant use of certain medications including Isoniazid, Antiepileptic drugs, Tyrosine kinase inhibitors and Alcohol. Acetaminophen may increase the international normalized ratio (INR) by potentiating the anticoagulant effect of warfarin. To prevent possible adverse drug interactions, the prescribers and pharmacists must discuss with their patients about the use of OTC Acetaminophen.
Number of views: 1114 Download in PDF
A Prospective Observational Study on Assessment of Adverse Drug Reactions in Patients taking First Line Antitubercular Drugs at Tertiary Care Teaching Hospital, Nellore
European Journal of Medicine, 2019, 7(1): 35-44.
Number of views: 1037 Download in PDF
5. Reneta Toshkova, Elissaveta Zvetkova, Ignat Ignatov, Georgi GluhchevEuropean Journal of Medicine, 2019, 7(1): 35-44.
Abstract:
Tuberculosis (TB) is a mycobacterial infection, which remains a leading infectious killer globally. Patients’ non-compliance, therapeutic failure and drug resistance may result due to the occurrence of adverse drug reactions of Antitubercular drugs. The aim of present study was to identify and analyse the adverse drug reactions caused by first-line antitubercular drugs in DOTS centre and tertiary care hospital in Nellore. This was a prospective observational study carried out in the Department of Pulmonology at AC Subba Reddy Government Medical College, a tertiary care teaching hospital, Nellore, Andhra Pradesh over a period of six months. During the study period, all the patients receiving treatment with first-line Antitubercular drugs who met the study criteria were included and monitored for adverse drug reactions and subjected to causality assessment. A total of 260 patients were followed during the study period, out of which 155 patients developed adverse drug reactions. Higher incidence of adverse drug reactions was observed in females (66.66 %) than males (57.77 %). Gastrointestinal system was affected most commonly by the ADRs of first-line antitubercular drugs. Most of the reported ADRs belonged to “possible” category as per WHO and Naranjo scales of causality assessment. And it has been identified that majority of ADRs fall in “mild” category according to Hartwig’ scale of severity assessment. The present study suggests that the involvement of clinical pharmacists in the monitoring and assessment of ADRs of Antitubercular drugs may help to minimize morbidity and improve patient compliance and achieve better therapeutic outcome.
Tuberculosis (TB) is a mycobacterial infection, which remains a leading infectious killer globally. Patients’ non-compliance, therapeutic failure and drug resistance may result due to the occurrence of adverse drug reactions of Antitubercular drugs. The aim of present study was to identify and analyse the adverse drug reactions caused by first-line antitubercular drugs in DOTS centre and tertiary care hospital in Nellore. This was a prospective observational study carried out in the Department of Pulmonology at AC Subba Reddy Government Medical College, a tertiary care teaching hospital, Nellore, Andhra Pradesh over a period of six months. During the study period, all the patients receiving treatment with first-line Antitubercular drugs who met the study criteria were included and monitored for adverse drug reactions and subjected to causality assessment. A total of 260 patients were followed during the study period, out of which 155 patients developed adverse drug reactions. Higher incidence of adverse drug reactions was observed in females (66.66 %) than males (57.77 %). Gastrointestinal system was affected most commonly by the ADRs of first-line antitubercular drugs. Most of the reported ADRs belonged to “possible” category as per WHO and Naranjo scales of causality assessment. And it has been identified that majority of ADRs fall in “mild” category according to Hartwig’ scale of severity assessment. The present study suggests that the involvement of clinical pharmacists in the monitoring and assessment of ADRs of Antitubercular drugs may help to minimize morbidity and improve patient compliance and achieve better therapeutic outcome.
Number of views: 1037 Download in PDF
Effects of Catholyte Water on the Development of Experimental Graffi Tumor on Hamsters
European Journal of Medicine, 2019, 7(1): 45-56.
Number of views: 1119 Download in PDF
6. Iliyana Yaneva, Valentin BalabanskiEuropean Journal of Medicine, 2019, 7(1): 45-56.
Abstract:
The paper describes the results of a pilot study aimed at the investigation of the influence of catholyte (electrolyzed alkaline water) on the development of tumors. In the experiments solid Graffi tumor was transplanted subcutaneously in the back of the experimental group of Golden Syrian hamsters. Tumor appearance and growth were registered every day. Blood parameters were measured on the 10th and 25th day after transplantation and blood smears were prepared. Hamsters treated with catholyte developed tumor with some delay compared to untreated (drinking tap water) ones. Also, the tumor growth was slow and the survival rate was increased. The analysis of blood parameters and cell morphology has shown significant differences in the value of some hematometric parameters and morphological changes of some blood cells. The obtained results suggest about the beneficial influence of catholyte and the possible use of it as a supporting non-invasive therapy of cancer diseases.
The paper describes the results of a pilot study aimed at the investigation of the influence of catholyte (electrolyzed alkaline water) on the development of tumors. In the experiments solid Graffi tumor was transplanted subcutaneously in the back of the experimental group of Golden Syrian hamsters. Tumor appearance and growth were registered every day. Blood parameters were measured on the 10th and 25th day after transplantation and blood smears were prepared. Hamsters treated with catholyte developed tumor with some delay compared to untreated (drinking tap water) ones. Also, the tumor growth was slow and the survival rate was increased. The analysis of blood parameters and cell morphology has shown significant differences in the value of some hematometric parameters and morphological changes of some blood cells. The obtained results suggest about the beneficial influence of catholyte and the possible use of it as a supporting non-invasive therapy of cancer diseases.
Number of views: 1119 Download in PDF
Traditional Herbal Therapy for Some Cardiovascular Diseases in Bulgaria
European Journal of Medicine, 2019, 7(1): 57-65.
Number of views: 1083 Download in PDF
7. European Journal of Medicine, 2019, 7(1): 57-65.
Abstract:
Traditional medicine is a cultural heritage. Herbs are the basic remedy in Bulgarian traditional medicine, the empirical knowledge of medicinal plants being passed down from generation to generation primarily by word of mouth. Most of the plants are used in Bulgarian traditional medicine (BTM) on the grounds of the experience gained over the centuries. As for the treatment of diseases of the cardiovascular system, the data contained in some Bulgarian handwritten remedy books published in the late 19th and early 20th century show that our people empirically used medicinal plants the pharmacological activity of which is proven today through experimental and clinical studies. Thus far, science has not discovered the mechanism of pharmacological action of a lot of the herbs that people used. The researches in this direction are still going on. Bulgarian herbal therapy makes its contribution to world science.
Traditional medicine is a cultural heritage. Herbs are the basic remedy in Bulgarian traditional medicine, the empirical knowledge of medicinal plants being passed down from generation to generation primarily by word of mouth. Most of the plants are used in Bulgarian traditional medicine (BTM) on the grounds of the experience gained over the centuries. As for the treatment of diseases of the cardiovascular system, the data contained in some Bulgarian handwritten remedy books published in the late 19th and early 20th century show that our people empirically used medicinal plants the pharmacological activity of which is proven today through experimental and clinical studies. Thus far, science has not discovered the mechanism of pharmacological action of a lot of the herbs that people used. The researches in this direction are still going on. Bulgarian herbal therapy makes its contribution to world science.
Number of views: 1083 Download in PDF