2 December 25, 2019
Articles
1. Alexander Bolkhovitinov, Viktor Krukowskikh, Serge Pankratov
Multi-Beam Interference Patterns of Living Sarcoma Cells may be Approximated by a Fractal Julia Set and Rieman Spheres or Fatou Components Decoded as a Siegel Discs
European Journal of Medicine, 2019, 7(2): 68-91.
Number of views: 830 Download in PDF
2. Ignat Ignatov, Christos Drossinakis, Reneta Toshkova, Elisaveta Zvetkova, Iliana Yaneva, Georgi GluhchevEuropean Journal of Medicine, 2019, 7(2): 68-91.
Abstract:
It’s well known, that the morphology of a carcinoma cells was studied many a time and oft (on repeated occasions) from the second part of the XX century. But mathematical approximations of such sarcoma cell structures are not very good on the grounds of non-regular semi-chaotic elements in morphogenesis and morphology of cancer cells. Many approximations in sarcoma oncology works are not applying for cell morphology as is, despite the fact of good morphological representation of sarcoma cells in different microscopic and specific-staining methods. Our work is a first work where the multi-beam interference patterns of living sarcoma cells are approximated by a fractal Julia set and Fatou components known as a Siegel discs.
It’s well known, that the morphology of a carcinoma cells was studied many a time and oft (on repeated occasions) from the second part of the XX century. But mathematical approximations of such sarcoma cell structures are not very good on the grounds of non-regular semi-chaotic elements in morphogenesis and morphology of cancer cells. Many approximations in sarcoma oncology works are not applying for cell morphology as is, despite the fact of good morphological representation of sarcoma cells in different microscopic and specific-staining methods. Our work is a first work where the multi-beam interference patterns of living sarcoma cells are approximated by a fractal Julia set and Fatou components known as a Siegel discs.
Number of views: 830 Download in PDF
Effects of Electromagnetic Fields over DNA Hydrogen Bonds of Hamsters with Implanted Graffi Tumor
European Journal of Medicine, 2019, 7(2): 92-98.
Number of views: 824 Download in PDF
3. Ignat Ignatov, Dimitar Mehandjiev, Paunka Vassileva, Dimitrinka Voykova, Stoil Karadzhov, Georgi Gluhchev, Nikolai IvanovEuropean Journal of Medicine, 2019, 7(2): 92-98.
Abstract:
Studies were conducted with model systems of bio influence (Drossinakis’ method) with electromagnetic (e.m.) fields and infrared thermal field (ITF) (Ignatov et al., 2013). The purpose of research is to analyze effects over DNA. Analysis of effects over water and physiological saline is carried out in the report. Results are achieved with blood serum of hamsters and physiological processes in hamsters with tumors. The water analyses have been conducted with Nonequilibrium Energy Spectrum (NES) and Differential Nonequilibrium Energy Spectrum (DNES) methods (Antonov, 1992; Ignatov, 1998). Experiments were carried out about the influence on tumor cells of mice in water. Reduction of DNES spectrum according to the control sample of cells in healthy animals was observed. (Antonov, 1992). Reduction is also observed in DNES spectrum in blood serum of people having oncological diseases, compared to the one of healthy people (Ignatov, 2012). Such a reduction is most prevalent in (-0.1387 eV; 8.95 μm; 1117 cm-1). In research of the effects of e.m. fields in water and blood serum from hamsters the range is (-0.08 – -0.14 eV) (8.9 –15.5μm) (645–1129 cm-1). Research is conducted for the effects over Graffi tumor that was implanted in hamsters (Toshkova et al., 2019). Studies are conducted with pH and oxidation redox potential (ORP) effects of e.m. fields over physiological saline (Gluhchev et al., 2019).
Studies were conducted with model systems of bio influence (Drossinakis’ method) with electromagnetic (e.m.) fields and infrared thermal field (ITF) (Ignatov et al., 2013). The purpose of research is to analyze effects over DNA. Analysis of effects over water and physiological saline is carried out in the report. Results are achieved with blood serum of hamsters and physiological processes in hamsters with tumors. The water analyses have been conducted with Nonequilibrium Energy Spectrum (NES) and Differential Nonequilibrium Energy Spectrum (DNES) methods (Antonov, 1992; Ignatov, 1998). Experiments were carried out about the influence on tumor cells of mice in water. Reduction of DNES spectrum according to the control sample of cells in healthy animals was observed. (Antonov, 1992). Reduction is also observed in DNES spectrum in blood serum of people having oncological diseases, compared to the one of healthy people (Ignatov, 2012). Such a reduction is most prevalent in (-0.1387 eV; 8.95 μm; 1117 cm-1). In research of the effects of e.m. fields in water and blood serum from hamsters the range is (-0.08 – -0.14 eV) (8.9 –15.5μm) (645–1129 cm-1). Research is conducted for the effects over Graffi tumor that was implanted in hamsters (Toshkova et al., 2019). Studies are conducted with pH and oxidation redox potential (ORP) effects of e.m. fields over physiological saline (Gluhchev et al., 2019).
Number of views: 824 Download in PDF
Research of Water Catholyte of Presence of Nascent (Atomic) Hydrogen (H*). Hydrogen and Nascent Hydrogen of the Reactions for Origin of Life in Hot Mineral Water
European Journal of Medicine, 2019, 7(2): 99-105.
Number of views: 782 Download in PDF
4. Naina Mohamed Pakkir MaideenEuropean Journal of Medicine, 2019, 7(2): 99-105.
Abstract:
A reaction is published for forming of nascent (atomic) hydrogen (H*) from hydronium ions (H3O+) in catholyte (Ignatov et al., 2015). It is also observed the production of nascent hydrogen in electrolysis in the transition to H2 (Mehandjiev et al., 2017a, b). For checking of the theoretical suggestion experiments with potassium permanganate (KMnО4) are conducted. Potassium permanganate is a strong oxidizing agent. In this compound, manganese is in the +7 oxidation state (Мn7+). In reduction process the color оf the aqueous solution of KMnO4 is changed and thus the process could be examined spectrophotometrically Described is a reaction that proves the presence of nascent hydrogen in catholyte using potassium permanganate (Parn et al., 2012). In order to avoid the influence of salts contained in water from other sources, deionized water is used for production of catholyte/anolyte. There is possibility nascent hydrogen to have been part of reaction for origin of life in hot mineral water in primary hydrosphere as result of contact with hydrogen from primary atmosphere with hydrogen and gas discharge (Ignatov, 2019).
A reaction is published for forming of nascent (atomic) hydrogen (H*) from hydronium ions (H3O+) in catholyte (Ignatov et al., 2015). It is also observed the production of nascent hydrogen in electrolysis in the transition to H2 (Mehandjiev et al., 2017a, b). For checking of the theoretical suggestion experiments with potassium permanganate (KMnО4) are conducted. Potassium permanganate is a strong oxidizing agent. In this compound, manganese is in the +7 oxidation state (Мn7+). In reduction process the color оf the aqueous solution of KMnO4 is changed and thus the process could be examined spectrophotometrically Described is a reaction that proves the presence of nascent hydrogen in catholyte using potassium permanganate (Parn et al., 2012). In order to avoid the influence of salts contained in water from other sources, deionized water is used for production of catholyte/anolyte. There is possibility nascent hydrogen to have been part of reaction for origin of life in hot mineral water in primary hydrosphere as result of contact with hydrogen from primary atmosphere with hydrogen and gas discharge (Ignatov, 2019).
Number of views: 782 Download in PDF
Drug Interactions of Dihydropyridine Calcium Channel Blockers (CCBs) involving CYP3A4 Enzymes
European Journal of Medicine, 2019, 7(2): 106-113.
Number of views: 797 Download in PDF
5. Athena Myrou, Theodoros Aslanidis, Triantafyllos Didangelos, Christos Savopoulos, Apostolos Chatzitolios, Dimitrios GrekasEuropean Journal of Medicine, 2019, 7(2): 106-113.
Abstract:
Dihydropyridine Calcium Channel Blockers (CCBs) are widely used as first-line agents to treat hypertension in black patients and in patients aged more than 55 years. They have been identified as the substrates of intestinal and hepatic CYP3A4 enzymes and this review focuses on possible drug-drug interactions of dihydropyridine CCBs involving CYP3A4 enzymes. As object drugs, the dihydropyridine CCBs involved in drug-drug interactions with drugs such as Macrolide antibiotics, Azole antifungals, Protease inhibitors and fruit juices like Grapefruit juice and Seville orange juice and increase the plasma concentrations of dihydropyridine CCBs resulting in enhanced adverse effects. In addition, the drugs like Rifampicin, Phenytoin, and other antiepileptics including Carbamazepine and Phenobarbital decrease the bioavailability of dihydropyridine CCBs. Moreover, as precipitant drugs dihydropyridine CCBs increase the plasma concentrations of Statins and Cyclosporine and decrease the therapeutic efficacy of Clopidogrel. The prescribers and pharmacists are required to be aware of the adverse drug interactions of dihydropyridine CCBs to prevent adverse outcomes.
Dihydropyridine Calcium Channel Blockers (CCBs) are widely used as first-line agents to treat hypertension in black patients and in patients aged more than 55 years. They have been identified as the substrates of intestinal and hepatic CYP3A4 enzymes and this review focuses on possible drug-drug interactions of dihydropyridine CCBs involving CYP3A4 enzymes. As object drugs, the dihydropyridine CCBs involved in drug-drug interactions with drugs such as Macrolide antibiotics, Azole antifungals, Protease inhibitors and fruit juices like Grapefruit juice and Seville orange juice and increase the plasma concentrations of dihydropyridine CCBs resulting in enhanced adverse effects. In addition, the drugs like Rifampicin, Phenytoin, and other antiepileptics including Carbamazepine and Phenobarbital decrease the bioavailability of dihydropyridine CCBs. Moreover, as precipitant drugs dihydropyridine CCBs increase the plasma concentrations of Statins and Cyclosporine and decrease the therapeutic efficacy of Clopidogrel. The prescribers and pharmacists are required to be aware of the adverse drug interactions of dihydropyridine CCBs to prevent adverse outcomes.
Number of views: 797 Download in PDF
Fibroblast Growth Factor 23 Can Serve as an Early Biomarker of Type 2 Diabetic Nephropathy Progression
European Journal of Medicine, 2019, 7(2): 114-119.
Number of views: 790 Download in PDF
6. Nedyalka ValchevaEuropean Journal of Medicine, 2019, 7(2): 114-119.
Abstract:
Fibroblast growth Factors (FGFs) are multifunctional proteins with a wide variety of effects. (1) Aim: The aim of the present study was to examine FGF23 levels in patients with type II diabetic nephropathy (DN) and its correlation with bone metabolism biomarkers (2) Methods-material: Demographic, history, clinical examination and laboratory data were recorded from 80 patients with type II diabetes mellitus and diabetic nephropathy, 31 patients with type II diabetes mellitus and normal renal function and 31 healthy volunteers. (3) Results: GFR in negatively related to FGF23 levels, especially in the progression form early (I, II) to late stage (II, IV) of diabetic nephropathy, while a moderate relation between 1.25(OH)2D3 and FGF23 was found only in stage III and IV of diabetic nephropathy. Weak or no correlation was noticed among other parameters. (4) Conclusions: FGF23 is related to early progression of diabetic nephropathy and to markers of bone metabolism in stage III and IV of DM related chronic renal disease. The latter is not valid for patients with DM with normal renal function. Future research is needed to clarify FGF 23 role as prognostic and therapeutic index.
Fibroblast growth Factors (FGFs) are multifunctional proteins with a wide variety of effects. (1) Aim: The aim of the present study was to examine FGF23 levels in patients with type II diabetic nephropathy (DN) and its correlation with bone metabolism biomarkers (2) Methods-material: Demographic, history, clinical examination and laboratory data were recorded from 80 patients with type II diabetes mellitus and diabetic nephropathy, 31 patients with type II diabetes mellitus and normal renal function and 31 healthy volunteers. (3) Results: GFR in negatively related to FGF23 levels, especially in the progression form early (I, II) to late stage (II, IV) of diabetic nephropathy, while a moderate relation between 1.25(OH)2D3 and FGF23 was found only in stage III and IV of diabetic nephropathy. Weak or no correlation was noticed among other parameters. (4) Conclusions: FGF23 is related to early progression of diabetic nephropathy and to markers of bone metabolism in stage III and IV of DM related chronic renal disease. The latter is not valid for patients with DM with normal renal function. Future research is needed to clarify FGF 23 role as prognostic and therapeutic index.
Number of views: 790 Download in PDF
Physicochemical and Microbiological Characteristics of Thermal Healing Spring Waters in the Districts of Varna and Burgas, Black Sea Region, Bulgaria
European Journal of Medicine, 2019, 7(2): 120-130.
Number of views: 792 Download in PDF
7. Yuri M. Kabanov, Dina A. Venskovich, Vladimir V. Trushchenko, Nikolai T. Stanski, Valentina A. Koloshkina, Inna M. DudarevaEuropean Journal of Medicine, 2019, 7(2): 120-130.
Abstract:
Defined are the physicochemical properties of healing thermal spring waters in the area of Burgas District. It is shown that according to 18 controlled parameters included in the research, the thermal healing spring water village of Shivarovo, thermal healing spring water village of Polyanovo, fulfill the required conditions for drinking water. The spring waters from the given four water sources are characterized by microbiological indicators, as the pathogenic micro-organisms are defined by the membrane method. It is established that thermal healing spring water Burgas Mineral baths, thermal healing spring water village of Shivarovo, thermal healing spring water of village of Polyanovo, fulfill the standard requirements. The healing water of village Judge, District ofBurgas does not conform to the physicochemical indicators given for fluorides, and microbiological indicators with regards to coliform bacteria, Escherichia coli and enterococci. Defined are the physicochemical properties of healing thermal and non-thermal spring waters in the area of Varna District. It is shown that according to 18 controlled parameters included in the research, the thermal healing spring water drilling №Р-83хКК “Saints Constantine and Helena”, thermal healing spring water Р-1х “Aquarium”, thermal healing spring water Р-106 х “Dom Mladost”, thermal healing spring water Р-161х Varna at “Primorski” swimming pool, fulfill the required conditions for drinking water. The spring waters from the given four water sources are characterized by microbiological indicators, as the pathogenic micro-organisms are defined by the membrane method. It is established that thermal healing spring water drilling №Р-83хКК “Saints Constantine and Helena”, thermal healing spring water Р-1х “Aquarium”, thermal healing spring water Р-106 х “Dom Mladost”, thermal healing spring water Р-161х Varna at “Primorski” swimming pool, fulfill the standard requirements. “The healing water” of village Goren Chiflik, District of Varna does not conform with the physicochemical indicators given for nitrates, and microbiological indicators with regards to coliform bacteria and enterococci.
Defined are the physicochemical properties of healing thermal spring waters in the area of Burgas District. It is shown that according to 18 controlled parameters included in the research, the thermal healing spring water village of Shivarovo, thermal healing spring water village of Polyanovo, fulfill the required conditions for drinking water. The spring waters from the given four water sources are characterized by microbiological indicators, as the pathogenic micro-organisms are defined by the membrane method. It is established that thermal healing spring water Burgas Mineral baths, thermal healing spring water village of Shivarovo, thermal healing spring water of village of Polyanovo, fulfill the standard requirements. The healing water of village Judge, District ofBurgas does not conform to the physicochemical indicators given for fluorides, and microbiological indicators with regards to coliform bacteria, Escherichia coli and enterococci. Defined are the physicochemical properties of healing thermal and non-thermal spring waters in the area of Varna District. It is shown that according to 18 controlled parameters included in the research, the thermal healing spring water drilling №Р-83хКК “Saints Constantine and Helena”, thermal healing spring water Р-1х “Aquarium”, thermal healing spring water Р-106 х “Dom Mladost”, thermal healing spring water Р-161х Varna at “Primorski” swimming pool, fulfill the required conditions for drinking water. The spring waters from the given four water sources are characterized by microbiological indicators, as the pathogenic micro-organisms are defined by the membrane method. It is established that thermal healing spring water drilling №Р-83хКК “Saints Constantine and Helena”, thermal healing spring water Р-1х “Aquarium”, thermal healing spring water Р-106 х “Dom Mladost”, thermal healing spring water Р-161х Varna at “Primorski” swimming pool, fulfill the standard requirements. “The healing water” of village Goren Chiflik, District of Varna does not conform with the physicochemical indicators given for nitrates, and microbiological indicators with regards to coliform bacteria and enterococci.
Number of views: 792 Download in PDF
Sensitive Periods in the Ontogenesis of a Person
European Journal of Medicine, 2019, 7(2): 131-135.
Number of views: 791 Download in PDF
8. European Journal of Medicine, 2019, 7(2): 131-135.
Abstract:
The article considers issues related to the development of motor abilities of a person in the process of ontogenesis. The author presents the analysis of the manifestation of sensitive (critical) periods in the development of motor abilities of individuals of different sex and age, which makes it possible to develop certain functions of the organism of a person purposefully and efficiently as well as to form stable motor skills. The article considers age and sex transformations of morphological characteristics: total body measurements, body mass, chest size and lungs volume as well as sex differentiations in the manifestation of sensitive periods. Dynamics of the quantity of the manifestation of sensitive periods in the development of motor abilities of both males and females within the range of 2 to 22 years old is studied. Motor abilities, which must be developed at every age period, are listed.
The article considers issues related to the development of motor abilities of a person in the process of ontogenesis. The author presents the analysis of the manifestation of sensitive (critical) periods in the development of motor abilities of individuals of different sex and age, which makes it possible to develop certain functions of the organism of a person purposefully and efficiently as well as to form stable motor skills. The article considers age and sex transformations of morphological characteristics: total body measurements, body mass, chest size and lungs volume as well as sex differentiations in the manifestation of sensitive periods. Dynamics of the quantity of the manifestation of sensitive periods in the development of motor abilities of both males and females within the range of 2 to 22 years old is studied. Motor abilities, which must be developed at every age period, are listed.
Number of views: 791 Download in PDF